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There are dozens of over-the-counter and prescription allergy medicines available. Most are antihistamines. But, because histamine is only one of many substances that cause allergy symptoms, these drugs do not work all the time. They do work effectively at easing the symptoms of sneezing and itching, but do not have much of an effect on congestion.
Antihistamines can cause several serious side effects. Most cause drowsiness. This is why they will say do not drink alcohol while taking. You must not take antihistamines while taking anti-anxiety medications either. Drugs for headaches, antidepressants and muscle relaxants can cause a user to lose consciousness!
Do not take antihistamines without a doctor's supervision if you have high blood pressure, diabetes, heart disease, cardiovascular disease, an enlarge prostate or hyperthyroidism.
All antihistamines can affect the heart's rhythm and some have been know to cause arrhythmia which can prove fatal.
Terfenadine and astemizole were taken off the market for this reason. But Fexofenadine, which is still available, is similar in chemical compounds to terfenadine. Fexofenadine may cause headache, cold, nausea, back pain, menstrual pain, drowsiness or coughing.
Ethylenediamines seem to cause more digestive problems than other antihistamines. Cyproheptadine causes increases in appetite and weight gain.
Most antihistamines are combined with decongestants, expectorants or anti-cough medicines to make a more complete medicine.